11/21/2023 0 Comments Midazolam antidote![]() ![]() HI-6 treatment reactivated soman inhibited plasma and RBC cholinesterase up to 40%. Therapeutic regime consisting of HI-6 (50 mg/kg, i.m), atropine (10 mg/kg, i.m) and midazolam (5 mg/kg, i.m) protected animals against soman (2 × LD 50, s.c) lethality completely at 2 h and 80% at 24 h. ![]() In the present study, we intend to study the efficacy of antidotes comprising of HI-6 (1-methoxy]-methyl]-2- pyridinium dichloride), atropine and midazolam on soman induced neurodegeneration and the expression of c-Fos, Calpain, and Bax levels in discrete rat brain areas. The biochemical changes that occur following nerve agent exposure needs to be elucidated to understand the mechanisms behind their long term neurological effects and to design better therapeutic drugs to block their multiple neurotoxic effects. Acute nerve agent exposure can cause rapid death or leads to multiple and long term neurological effects. You may report side effects to FDA at 1-80.Recent alleged attacks with nerve agent sarin on civilians in Syria indicate their potential threat to both civilian and military population. Call your doctor for medical advice about side effects. This is not a complete list of side effects and others may occur. Use caution to avoid falling or accidental injury.Ĭommon side effects of midazolam may include:Īmnesia or forgetfulness after your procedure Tell your medical caregivers right away if you have:Ī light-headed feeling, like you might pass out Ĭonfusion, agitation, hallucinations, unusual thoughts or behavior.ĭrowsiness or dizziness may last longer in older adults. Your caregivers will watch you for symptoms such as weak or shallow breathing. ![]() Midazolam can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing. Get emergency medical help if you have signs of an allergic reaction: hives difficult breathing swelling of your face, lips, tongue, or throat. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |